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Literature summary for 5.4.99.7 extracted from

  • Balliano, G.; Milla, P.; Ceruti, M.; Viola, F.; Carrano, L.; Cattel, L.
    Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene (1993), FEBS Lett., 320, 203-206.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-Epoxy-10-aza-10,11-dehydrosqualene 6E isomer strongly inhibits enzyme in both cell cultures and microsomes; weak inhibition by 6Z isomer Candida albicans
2,3-Epoxy-10-aza-10,11-dehydrosqualene 6E isomer strongly inhibits enzyme in both cell cultures and microsomes; 6Z isomer has no effect on microsomal enzyme Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Saccharomyces cerevisiae
-
-
microsome
-
Candida albicans
-
-

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Saccharomyces cerevisiae
-
cell culture
-
Candida albicans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-squalene-2,3-epoxide
-
Saccharomyces cerevisiae Lanosterol
-
?
(S)-squalene-2,3-epoxide
-
Candida albicans Lanosterol
-
?