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Literature summary for 5.4.99.5 extracted from

  • Hediger, M.E.
    Design, synthesis, and evaluation of aza inhibitors of chorismate mutase (2004), Bioorg. Med. Chem., 12, 4995-5010.
    View publication on PubMed
Search for more literature for 5.4.99.5

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(1R,2S,3S,5S,7S)-10-hydroxy-3-oxo-2-oxa-5-azatricyclo[4.3.1.1(4,8)]undecane-8-carboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
(1R,3R,5S,8R)-2-azatricyclo[3.3.1.0(1,8)]-non-6-ene-3,5-dicarboxylate exo arizidine analogue, no time-dependent loss of activity is observed in the presence of this potentially reactive aza inhibitor Escherichia coli
(1R,3R,5S,8S)-8-hydroxy-2-azabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
(1R,3S,5S,8S)-8-hydroxy-2-azabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
(1S,4S,6R,8S,10S)-3-oxo-5-aza-2-oxa-tetracyclo[4.3.1.(4,8).0(6,10)]undecane-8-carboxylate tetracyclic lactone, no time-dependent loss of activity is observed in the presence of this potentially reactive aza inhibitor Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chorismate Escherichia coli
-
 Prephenate
-
 ?
Chorismate Escherichia coli JFM-30
-
 Prephenate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli JFM-30
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Storage Stability

Storage Stability Organism
-78°C, 100 mM N-ethylmorpholine, 1.0 mM dithioerythritol, 1.0 mM N-ethylene-diaminetetraacetic acid, 21 mM trisodium citrate, 10% (v/v) glycerol in doubly distilled water adjusted to pH 7.0 with concentrated HCl Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate
-
 Escherichia coli Prephenate
-
 ?
Chorismate
-
 Escherichia coli JFM-30 Prephenate
-
 ?

Synonyms

Synonyms Comment Organism
chorismate mutase
-
 Escherichia coli