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Literature summary for 5.4.99.25 extracted from
- Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance (2002), Microbiology, 148, 3511-3520.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P60340 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pseuduridine-55 synthase | - |
Escherichia coli |
| PSI55 synthaseuB | - |
Escherichia coli |
| TR | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a truB null mutant grows normally on all growth media tested, but exhibits a competitive disadvantage in extended co-culture with its wild-type progenitor. The mutant phenotype can be complemented by both the cloned truB gene and by a D48C, catalytically inactive allele of truB. The truB mutant also exhibits a defect in survival of rapid transfer from 37 to 50°C | Escherichia coli |
| physiological function | pseudouridine-55 synthase is responsible for modifying all tRNA molecules in the cell at the uridine55 position. TruB-effected pseudouridine55 modification of tRNA is not essential, but contributes to thermal stress tolerance in Escherichia. coli, possibly by optimizing the stability of the tRNA population at high temperatures | Escherichia coli |
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