Literature summary for 5.4.99.2 extracted from

Retey, J.; Smith, E.H.; Zagalak, B.
Investigation of the mechanism of the methylmalonyl-CoA mutase reaction with the substrate analogue: ethylmalonyl-CoA (1978), Eur. J. Biochem., 83, 437-451.

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Organism

Organism	UniProt	Comment	Textmining
Propionibacterium freudenreichii subsp. shermanii	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(R)-methylmalonyl-CoA = succinyl-CoA	mechanism	Propionibacterium freudenreichii subsp. shermanii	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ethylmalonyl-CoA	reacts about 1000-10000 times moreslowly than the natural substrate	Propionibacterium freudenreichii subsp. shermanii	(2R)-Methylsuccinyl-CoA	+ a small amount of (2S)-diastereoisomer	?

Cofactor

Cofactor	Comment	Organism	Structure
Cobalamin	-	Propionibacterium freudenreichii subsp. shermanii

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Release 2023.1 (January 2023)