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Literature summary for 5.4.99.17 extracted from

  • Rocco, F.; Bosso, S.O.; Viola, F.; Milla, P.; Roma, G.; Grossi, G.; Ceruti, M.
    Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases (2003), Lipids, 38, 201-207.
    View publication on PubMed
Search for more literature for 5.4.99.17

Inhibitors

Inhibitors Comment Organism Structure
(18E)-29-methylidenehexanor-2,3-oxidosqualene IC50 0.2 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius
(1E,3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-methylthio-1,3,7,11-heptadecatetraene IC50 1 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius
(1E,3E,7E,11E,15E)-19,20-epoxy-7,12,16,20-tetramethyl-1-methylthio-1,3,7,11,15-heneicosapentaene IC50 1.4 microMol, pH 6.0, 55°C, not time-dependency up to 10fold higher concentration than IC50 Alicyclobacillus acidocaldarius
(1Z,3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-methylthio-1,3,7,11-heptadecatetraene IC50 4 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius
(1Z,3E,7E,11E,15E)-19,20-epoxy-7,12,16,20-tetramethyl-1-methylthio-1,3,7,11,15-heneicosapentaene IC50 1.8 microMol, pH 6.0, 55°C, not time-dependency up to 10fold higher concentration than IC50 Alicyclobacillus acidocaldarius
(3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-phenylthio-1,3,7,11-heptadecatetraene IC50 2.2 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius
(5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-phenylthio-1,5,9-pentadecatriene IC50 7 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius
(5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-phenylthio-1,5,9,13-nonadecatetraene IC50 3 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius

Organism

Organism UniProt Comment Textmining
Alicyclobacillus acidocaldarius
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene
-
 Alicyclobacillus acidocaldarius hopene
-
 ?

Synonyms

Synonyms Comment Organism
SHC
-
 Alicyclobacillus acidocaldarius

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 IC50 0.2 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (18E)-29-methylidenehexanor-2,3-oxidosqualene
0.001
-
 IC50 1 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (1E,3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-methylthio-1,3,7,11-heptadecatetraene
0.0014
-
 IC50 1.4 microMol, pH 6.0, 55°C, not time-dependency up to 10fold higher concentration than IC50 Alicyclobacillus acidocaldarius (1E,3E,7E,11E,15E)-19,20-epoxy-7,12,16,20-tetramethyl-1-methylthio-1,3,7,11,15-heneicosapentaene
0.0018
-
 IC50 1.8 microMol, pH 6.0, 55°C, not time-dependency up to 10fold higher concentration than IC50 Alicyclobacillus acidocaldarius (1Z,3E,7E,11E,15E)-19,20-epoxy-7,12,16,20-tetramethyl-1-methylthio-1,3,7,11,15-heneicosapentaene
0.0022
-
 IC50 2.2 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-phenylthio-1,3,7,11-heptadecatetraene
0.003
-
 IC50 3 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-phenylthio-1,5,9,13-nonadecatetraene
0.004
-
 IC50 4 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (1Z,3E,7E,11E)-15,16-epoxy-8,12,16-trimethyl-1-methylthio-1,3,7,11-heptadecatetraene
0.007
-
 IC50 7 microMol, pH 6.0, 55°C Alicyclobacillus acidocaldarius (5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-phenylthio-1,5,9-pentadecatriene