Literature summary for 5.4.99.11 extracted from

Ravaud, S.; Robert, X.; Watzlawick, H.; Haser, R.; Mattes, R.; Aghajari, N.
Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization (2007), J. Biol. Chem., 282, 28126-28136.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-type in native state and in complex with competitive inhibitors Tris, deoxynojirimycin, and castanospermine, and inactive mutants D200A, and E254Q, in complex with D-glucose and sucrose	Paraburkholderia acidicola

Inhibitors

Inhibitors	Comment	Organism	Structure
castanospermine	competitive, crystal structure in complex with enzyme	Paraburkholderia acidicola
deoxynojirimycin	competitive, crystal structure in complex with enzyme	Paraburkholderia acidicola
additional information	not inhibitory: acarbose	Paraburkholderia acidicola
Tris(hydroxymethyl)aminomethane	competitive, crystal structure in complex with enzyme	Paraburkholderia acidicola

Organism

Organism	UniProt	Comment	Textmining
Paraburkholderia acidicola	-	-	-
Paraburkholderia acidicola MX-45	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.015	-	castanospermine	-	Paraburkholderia acidicola
0.04	-	deoxynojirimycin	-	Paraburkholderia acidicola

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Release 2023.1 (January 2023)