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Literature summary for 5.4.4.2 extracted from

  • Villajuana-Bonequi, M.; Elrouby, N.; Nordstroem, K.; Griebel, T.; Bachmair, A.; Coupland, G.
    Elevated salicylic acid levels conferred by increased expression of isochorismate synthase 1 contribute to hyperaccumulation of SUMO1 conjugates in the Arabidopsis mutant early in short days 4 (2014), Plant J., 79, 206-219 .
    View publication on PubMed
Search for more literature for 5.4.4.2

Protein Variants

Protein Variants Comment Organism
additional information genetic mapping and genome sequencing indicate that mutation sed111 is in the gene salicylic acid induction-deficient 2 (SID2), which encodes isochorismate synthase 1, ICS1. Mutation sed111 belongs to a series of mutants called suppressor of esd4 (sed), which delay flowering, enhance growth and reduce hyperaccumulation of SUMO conjugates. Mutations in the SUMO protease early in short days 4 (ESD4) cause hyperaccumulation of conjugates formed between SUMO and its substrates, and phenotypically are associated with extreme early flowering and impaired growth. Compared to wild-type plants, esd4 contains higher levels of SID2 mRNA and about threefold more salicylate, whereas sed111 contains lower salicylate levels. Other sed mutations also reduce the high SID2 mRNA abundance and free salicylate levels found in esd4-1. Sed, esd, and sid mutation analysis in Arabidopsis thaliana, detailed overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chorismate Arabidopsis thaliana
-
 Isochorismate
-
 r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9S7H8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate
-
 Arabidopsis thaliana Isochorismate
-
 r

Synonyms

Synonyms Comment Organism
ICS1
-
 Arabidopsis thaliana
isochorismate synthase 1
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana elevated salicylic acid levels confer increased expression of isochorismate synthase 1, ICS1 up

General Information

General Information Comment Organism
malfunction mutation sed111 in the gene salicylic acid induction-deficient 2 (SID2), which encodes isochorismate synthase 1. Mutation sed111 belongs to a series of mutants called suppressor of esd4 (sed), which delay flowering, enhance growth and reduce hyperaccumulation of SUMO conjugates. Mutations in the SUMO protease early in short days 4 (ESD4) cause hyperaccumulation of conjugates formed between SUMO and its substrates, and phenotypically are associated with extreme early flowering and impaired growth. Elevated salicylic acid levels conferred by increased expression of isochorismate synthase 1 contribute to hyperaccumulation of SUMO1 conjugates in the Arabidopsis thaliana mutant early in short days 4. Compared to wild-type plants, esd4 contains higher levels of SID2 mRNA and about threefold more salicylate, whereas sed111 contains lower salicylate levels Arabidopsis thaliana
physiological function isochorismate synthase 1 is required for salicylate biosynthesis. SUMO homeostasis influences salicylate biosynthesis in wild-type plants, and also demonstrate that elevated levels of salicylate strongly increase the abundance of SUMO conjugates Arabidopsis thaliana