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Literature summary for 5.4.4.2 extracted from
- Pericyclic reactions catalyzed by chorismate-utilizing enzymes (2011), Biochemistry, 50, 7476-7483.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required, chelated by residues D310, E313, and H348 | Pseudomonas aeruginosa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Chorismate | Pseudomonas aeruginosa | - |
Isochorismate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Chorismate | - |
Pseudomonas aeruginosa | Isochorismate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PchA | - |
Pseudomonas aeruginosa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme produces isochorismate for conversion to salicylate by isochorismate-pyruvate lyase, PchB, and incorporation into the pyochelin siderophore. Isochorismate synthase (PchA) and isochorismate-pyruvate lyase (PchB) from Pseudomonas aeurginosa are involved in the synthesis of the siderophore pyochelin | Pseudomonas aeruginosa |
| additional information | structure-function relationships of chorismate-utilizing enzymes, structure comparisons, overview. Isochorismate synthase cannot perform any pericyclic reaction. Residues K221 and E269 are general base and acid, respectively | Pseudomonas aeruginosa |
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