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Literature summary for 5.4.2.8 extracted from

  • Citro, V.; Cimmaruta, C.; Liguori, L.; Viscido, G.; Cubellis, M.V.; Andreotti, G.
    A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP Possible implications for the disease PMM2-CDG (2017), PLoS ONE, 12, e0189629 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.8

Activating Compound

Activating Compound Comment Organism Structure
D-Glucose 1,6-bisphosphate
-
 Homo sapiens
D-Mannose 1,6-bisphosphate
-
 Homo sapiens
inosine monophosphate the phosphatase activity of isoform PMM1 is enhanced by inosine monophosphate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
clodronate specific inhibitor; specific inhibitor Homo sapiens
inosine monophosphate inhibits competitively the mutase activity of isoform PMM1 Homo sapiens
additional information not inhibited by neridronate; not inhibited by neridronate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0065
-
 alpha-D-mannose 1-phosphate isoform PMM1, at pH 7.5 and 32°C Homo sapiens
0.0073
-
 alpha-D-glucose 1-phosphate isoform PMM1, at pH 7.5 and 32°C Homo sapiens
0.0082
-
 alpha-D-glucose 1-phosphate isoform PMM2, at pH 7.5 and 32°C Homo sapiens
0.0237
-
 alpha-D-mannose 1-phosphate isoform PMM2, at pH 7.5 and 32°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15305
-
-
Homo sapiens Q92871
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1-phosphate
-
 Homo sapiens D-glucose 6-phosphate
-
 ?
alpha-D-mannose 1-phosphate
-
 Homo sapiens D-mannose 6-phosphate
-
 ?
additional information D-glucose 1,6-bisphosphate and D-mannose 1,6-bisphosphate can be hydrolyzed by isoform PMM1 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphomannomutase 1
-
 Homo sapiens
phosphomannomutase 2
-
 Homo sapiens
PMM1
-
 Homo sapiens
PMM2
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
43
-
 melting temperature of isoform PMM1 Homo sapiens