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Literature summary for 5.4.2.12 extracted from

  • Foster, J.M.; Raverdy, S.; Ganatra, M.B.; Colussi, P.A.; Taron, C.H.; Carlow, C.K.
    The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapies (2009), Parasitol. Res., 104, 1047-1052.
    View publication on PubMed

Application

Application Comment Organism
medicine drug target for novel anti-filarial therapies that selectively target the Wolbachia endosymbiont of Brugia malayi Wolbachia sp.

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli (inactive unsoluble protein) and Kluyveromyces lactis (active enzyme) Wolbachia sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
deduced from sequence of cDNA Wolbachia sp.
100000
-
around 100000 Da, SDS-PAGE, enzyme fused with N-terminal maltose binding protein Wolbachia sp.

Organism

Organism UniProt Comment Textmining
Wolbachia sp. Q5GSN3
-
-

Purification (Commentary)

Purification (Comment) Organism
amylose column chromatography Wolbachia sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
Wolbachia sp. 3-phospho-D-glycerate
-
r

Synonyms

Synonyms Comment Organism
iPGM
-
Wolbachia sp.

Cofactor

Cofactor Comment Organism Structure
additional information cofactor-independent Wolbachia sp.