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Literature summary for 5.4.2.12 extracted from

  • Zhang, Y.; Foster, J.M.; Kumar, S.; Fougere, M.; Carlow, C.K.
    Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes (2004), J. Biol. Chem., 279, 37185-37190.
    View publication on PubMed
Search for more literature for 5.4.2.12

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli with His6-tag Caenorhabditis elegans
expression in Escherichia coli with His6-tag Brugia malayi

Protein Variants

Protein Variants Comment Organism
additional information reduction of enzyme activity by RNA interference leads to embroynic lethality, larval lethylity, and abnormal body morphology Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: vanadate Brugia malayi
additional information not inhibitory: vanadate Caenorhabditis elegans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 x * 60000, SDS-PAGE Caenorhabditis elegans
60000
-
 x * 60000, SDS-PAGE Brugia malayi

Organism

Organism UniProt Comment Textmining
Brugia malayi Q4VWF8
-
-
Caenorhabditis elegans G5EFZ1
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
40
-
 pH 7.0, 30°C, formation of 2-phospho-D-glycerate Caenorhabditis elegans
72
-
 pH 7.0, 30°C, formation of 3-phospho-D-glycerate Caenorhabditis elegans
93
-
 pH 7.0, 30°C, formation of 2-phospho-D-glycerate Brugia malayi
256
-
 pH 7.0, 30°C, formation of 3-phospho-D-glycerate Brugia malayi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
 Caenorhabditis elegans 3-phospho-D-glycerate
-
 r
2-phospho-D-glycerate
-
 Brugia malayi 3-phospho-D-glycerate
-
 r
3-phospho-D-glycerate
-
 Caenorhabditis elegans 2-phospho-D-glycerate
-
 r
3-phospho-D-glycerate
-
 Brugia malayi 2-phospho-D-glycerate
-
 r

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Caenorhabditis elegans
? x * 60000, SDS-PAGE Brugia malayi

Cofactor

Cofactor Comment Organism Structure
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Caenorhabditis elegans
additional information 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Brugia malayi