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Literature summary for 5.4.2.11 extracted from

  • Xu, Z.; Gong, J.; Wang, C.; Wang, Y.; Song, Y.; Xu, W.; Liu, Z.; Liu, Y.
    The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma (2016), Oncol. Rep., 36, 2236-2244 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phospho-D-glycerate Homo sapiens
-
3-phospho-D-glycerate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P18669
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
glioma cell
-
Homo sapiens
-
U-87 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
Homo sapiens 3-phospho-D-glycerate
-
?

Synonyms

Synonyms Comment Organism
PGAM1
-
Homo sapiens
phosphoglycerate mutase 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the mRNA and protein expression of the enzyme is significantly greater in glioma than normal brain tissues up

General Information

General Information Comment Organism
malfunction enzyme knockdown significantly inhibits glioma cell proliferation, promotes glioma cell apoptosis, induces S phase cell cycle arrest and inhibits glioma cell migration and invasion in vitro Homo sapiens
physiological function the enzyme is associated with the grade of glioma and is involved in the biological behavior of glioma cells Homo sapiens