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Literature summary for 5.4.2.10 extracted from
- Effect of phosphoglucosamine mutase on biofilm formation and antimicrobial susceptibilities in M. smegmatis glmM gene knockdown strain (2013), PLoS ONE, 8, e61589.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene glmM, subcloning in Escherichia coli strain NOvaBlue | Mycolicibacterium smegmatis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of a glmM knockout strain with highly reduced enzyme activity, growth of the strain is inducible by tetracycline, cells show morphological changes, phenotype, overview | Mycolicibacterium smegmatis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucosamine 1-phosphate | Mycolicibacterium smegmatis | - |
D-glucosamine 6-phosphate | - |
r |  |
| alpha-D-glucosamine 1-phosphate | Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | - |
D-glucosamine 6-phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycolicibacterium smegmatis | - |
gene glmM | - |
| Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | - |
gene glmM | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucosamine 1-phosphate | - |
Mycolicibacterium smegmatis | D-glucosamine 6-phosphate | - |
r | |
| alpha-D-glucosamine 1-phosphate | - |
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | D-glucosamine 6-phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlmM | - |
Mycolicibacterium smegmatis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme knockdown results in a decline of cell growth | Mycolicibacterium smegmatis |
| metabolism | phosphoglucosamine mutase is involved in the formation of glucosamine-1-phosphate from glucosamine-6-phosphate, the second step in UDP-GlcNAc biosynthetic pathway | Mycolicibacterium smegmatis |
| physiological function | the enzyme is essential for the growth of Mycobacterium smegmatis | Mycolicibacterium smegmatis |
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Release 2023.1 (January 2023)
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