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Literature summary for 5.3.99.5 extracted from

  • Schmidt, N.O.; Ziu, M.; Cargioli, T.; Westphal, M.; Giese, A.; Black, P.M.; Carroll, R.S.
    Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy (2010), Transl. Oncol., 3, 43-49.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.99.5

Application

Application Comment Organism
medicine the targeted inhibition of TXSA activity improves the efficiency of conventional alkylation chemotherapy in vivo Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
furegrelate specific inhibitor of TXSA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin H2 Homo sapiens
-
 thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin H2
-
 Homo sapiens thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
thromboxane synthase
-
 Homo sapiens
TXSA
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens TXSA is upregulated in human glial tumors up