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Literature summary for 5.3.99.5 extracted from

  • Gabrielsen, A.; Qiu, H.; Baeck, M.; Hamberg, M.; Hemdahl, A.L.; Agardh, H.; Folkersen, L.; Swedenborg, J.; Hedin, U.; Paulsson-Berne, G.; Haeggstroem, J.Z.; Hansson, G.K.
    Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion (2010), J. Mol. Med., 88, 795-806.
    View publication on PubMed
Search for more literature for 5.3.99.5

Inhibitors

Inhibitors Comment Organism Structure
furegrelate
-
 Homo sapiens
furegrelate
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin H2 Mus musculus
-
 thromboxane A2
-
 ?
prostaglandin H2 Homo sapiens
-
 thromboxane A2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages Mus musculus
-
aorta TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin H2
-
 Mus musculus thromboxane A2
-
 ?
prostaglandin H2
-
 Homo sapiens thromboxane A2
-
 ?

Synonyms

Synonyms Comment Organism
thromboxane synthase
-
 Mus musculus
thromboxane synthase
-
 Homo sapiens
TXAS
-
 Mus musculus
TXAS
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels additional information
Homo sapiens inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels additional information
Homo sapiens TXAS increases in atherosclerotic lesions of patients with recent symptoms of thrombotic events up
Mus musculus TXAS mRNA expression is increased within the vascular wall in mouse models of atherosclerosis with advanced lesions up