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Literature summary for 5.3.99.5 extracted from

  • Nusing, R.; Schneider-Voss, S.; Ullrich, V.
    Immunoaffinity purification of human thromboxane synthase (1990), Arch. Biochem. Biophys., 280, 325-330.
    View publication on PubMed
Search for more literature for 5.3.99.5

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 prostaglandin H2
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
one-step immunoaffinity purification Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.255
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1 ?

Subunits

Subunits Comment Organism
?
-
 Homo sapiens
monomer x * 58000, SDS-PAGE Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme hemoprotein Homo sapiens
heme contains one heme per 58000 MW protein. The major part of the enzyme is converted by the elution procedure to the inactive P420 form, a minor part is in its native heme-thiolate conformation Homo sapiens