Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.99.5 extracted from

  • Hammarstroem, S.; Diczfalusy, U.
    Inhibition and properties of thromboxane synthetase (1979), Adv. Inflamm. Res., 1, 431-438.
No PubMed abstract available
Search for more literature for 5.3.99.5

Inhibitors

Inhibitors Comment Organism Structure
1(omega-Carboxylalkyl)imidazoles very potent Homo sapiens
1-Methyl imidazole
-
 Homo sapiens
2-Isopropyl-3-nicotinylindole
-
 Homo sapiens
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate i.e. N-0164 Homo sapiens
9,11(Epoxymethano) prostanoic acid
-
 Homo sapiens
9,11-Azo-15-hydroxyprosta-5,13-dienoic acid
-
 Homo sapiens
9,11-Azoprosta-5,13-dienoic acid
-
 Homo sapiens
9,11-Epoxymethano-15-hydroxy-prosta-5,13-dienoic acid
-
 Homo sapiens
Benzydamine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 prostaglandin G2 + H2O i.e. PGG2 Homo sapiens 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
 ?
prostaglandin H1
-
 Homo sapiens 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid ?
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2 ?
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid + malondialdehyde ?
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1 ?