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Literature summary for 5.3.99.4 extracted from

  • He, C.; Choi, H.C.; Xie, Z.
    Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients (2010), Am. J. Pathol., 176, 2542-2549.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine tyrosine nitration of prostacyclin synthase is correlated with an excessive inflammatory response in atherosclerotic carotid arteries from patients with type 2 diabetes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
Prostaglandin I2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information diabetes induces prostacyclin synthase nitration in carotid plaques Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell HAEC Homo sapiens
-
carotid artery
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Homo sapiens Prostaglandin I2
-
?

Synonyms

Synonyms Comment Organism
PGIS
-
Homo sapiens
prostacyclin synthase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity down