Application | Comment | Organism |
---|---|---|
medicine | tyrosine nitration of prostacyclin synthase is correlated with an excessive inflammatory response in atherosclerotic carotid arteries from patients with type 2 diabetes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | diabetes induces prostacyclin synthase nitration in carotid plaques | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic endothelial cell | HAEC | Homo sapiens | - |
carotid artery | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGIS | - |
Homo sapiens |
prostacyclin synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity | down |