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Literature summary for 5.3.99.4 extracted from

  • Camacho, M.; Rodriguez, C.; Salazar, J.; Martinez-Gonzalez, J.; Ribalta, J.; Escudero, J.R.; Masana, L.; Vila, L.
    Retinoic acid induces PGI synthase expression in human endothelial cells (2008), J. Lipid Res., 49, 1707-1714.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
13-cis-retinoic acid induces prostaglandin-I synthase activity and expression of mRNA and protein, mediated by retinoic acid receptor. Actinomycin and cycloheximide both inhibit the retinoic acid-induced expression. 13-cis-Retinoic acid additionally increases the release of prostaglandin I2, both spontaneous and thrombin-induced. Co-incubation with 13-cis-retinoic acid and interleukin-1beta results in a synergic increase in the release of prostaglandin I2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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Homo sapiens
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