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Literature summary for 5.3.99.4 extracted from

  • Griffoni, C.; Spisni, E.; Strillacci, A.; Toni, M.; Bachschmid, M.M.; Tomasi, V.
    Selective inhibition of prostacyclin synthase activity by rofecoxib (2007), J. Cell. Mol. Med., 11, 327-338.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
rofecoxib inhibitor of cyclooxygenase COX-2, additionally non-competitive inhibition of prostacyclin synthase in aortic microsomal fractions. No significant inhibition up to 0.001 mM Bos taurus
rofecoxib inhibitor of cyclooxygenase COX-2, additionally non-competitive inhibition of prostacyclin synthase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Bos taurus
-
HUVEC cell
-
Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
22°C, 0.001 mM rofecoxib completely blocks cyclooxygenase COX-2 Homo sapiens rofecoxib
0.01
-
22°C. No significant inhibition up to 0.001 mM Bos taurus rofecoxib