Literature summary for 5.3.99.4 extracted from

Keith, R.L.; Miller, Y.E.; Hudish, T.M.; Girod, C.E.; Sotto-Santiago, S.; Franklin, W.A.; Nemenoff, R.A.; March, T.H.; Nana-Sinkam, S.P.; Geraci, M.W.
Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice (2004), Cancer Res., 64, 5897-5904.

Search for more literature for 5.3.99.4

Application

Application	Comment	Organism
medicine	manipulation of prostaglandin production distal to cyclooxygenase significantly reduces lung carcinogenesis in a tobacco smoke exposure model	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in alveolar and airway epithelial cells from Mus musculus	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Prostaglandin H2	Rattus norvegicus	-	Prostaglandin I2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Prostaglandin H2	-	Rattus norvegicus	Prostaglandin I2	-	?
prostaglandin H2	-	Rattus norvegicus	6-keto prostaglandin F1-alpha	-	?

Synonyms

Synonyms	Comment	Organism
prostacyclin synthase	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)