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Literature summary for 5.3.99.4 extracted from

  • Wu, K.K.; Liou, J.Y.
    Cellular and molecular biology of prostacyclin synthase (2005), Biochem. Biophys. Res. Commun., 338, 45-52.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the extent of prostaglandin I2 production is determined by an appropriate ratio of COX-1/COX-2 to PGIS. Human vascular endothelial cells transfected with a construct that contains COX-1 and prostaglandin-I synthase cDNAs have an equivalent increase in COX-1 and PGIS, and produce a large quantity of prostaglandin-I synthase which is more than 200fold over that produced by untransfected cells Homo sapiens

Application

Application Comment Organism
medicine overexpression of PGIS is highly effective in controlling vascular diseases and ischemia-reperfusion tissue injury, gene transfer of bicistronic COX-1/PGIS has the potential for treatment of diverse clinical disorders including vascular diseases, pulmonary hypertension, and ischemia-reperfusion cerebral and cardiac injury Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
from endothelilal cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is deactivated by prostaglandin H2 and peroxides Bos taurus
additional information the enzyme is deactivated by prostaglandin H2 and peroxides Homo sapiens
peroxynitrite inhibits PGIS activity by nitration of tyrosine 430 Bos taurus
peroxynitrite inhibits PGIS activity by nitration of Tyr 430 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER Mus musculus 16020
-
membrane anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER Homo sapiens 16020
-
membrane anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER Bos taurus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
-
Bos taurus
56000
-
-
Homo sapiens
56000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
Prostaglandin I2
-
?
Prostaglandin H2 Homo sapiens
-
Prostaglandin I2
-
?
Prostaglandin H2 Bos taurus
-
Prostaglandin I2
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
-
aorta
-
Bos taurus
-
blastocyst
-
Mus musculus
-
blood platelet microsomal fraction Homo sapiens
-
blood platelet microsomal fraction Bos taurus
-
embryo
-
Mus musculus
-
oviduct
-
Mus musculus
-
oviduct
-
Homo sapiens
-
vascular endothelial cell
-
Mus musculus
-
vascular endothelial cell
-
Homo sapiens
-
vascular endothelial cell
-
Bos taurus
-
vascular smooth muscle cell
-
Mus musculus
-
vascular smooth muscle cell
-
Homo sapiens
-
vascular smooth muscle cell
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Mus musculus Prostaglandin I2
-
?
Prostaglandin H2
-
Homo sapiens Prostaglandin I2
-
?
Prostaglandin H2
-
Bos taurus Prostaglandin I2
-
?

Synonyms

Synonyms Comment Organism
PGIS
-
Mus musculus
PGIS
-
Homo sapiens
PGIS
-
Bos taurus
prostacyclin synthase
-
Mus musculus
prostacyclin synthase
-
Homo sapiens
prostacyclin synthase
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus
heme
-
Homo sapiens
heme
-
Bos taurus