Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-hydroxy-DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
ajulemic acid | - |
Homo sapiens | |
cannabidiol | - |
Homo sapiens | |
DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
additional information | not inhibited by oleamide, palmitoylethanolamide, oleoylethanolamide, prostamide F2alpha, N-arachidonoylethanolamine/anandamide, and 2-arachidonoylglycerol | Homo sapiens | |
oleic acid | - |
Homo sapiens | |
palmitoleic acid | - |
Homo sapiens | |
prostaglandin E2 | - |
Homo sapiens | |
prostaglandin E2-glyceryl ester | - |
Homo sapiens | |
prostaglandin F2alpha | - |
Homo sapiens | |
SBFI-26 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin D2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-PGDS | - |
Homo sapiens |
lipocalin-type prostaglandin d synthase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0018 | - |
oleic acid | at pH 7.6 and 25°C | Homo sapiens | |
0.0022 | - |
ajulemic acid | at pH 7.6 and 25°C | Homo sapiens | |
0.003 | - |
SBFI-26 | at pH 7.6 and 25°C | Homo sapiens | |
0.0037 | - |
palmitoleic acid | at pH 7.6 and 25°C | Homo sapiens | |
0.0078 | - |
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens | |
0.0112 | - |
prostaglandin E2-glyceryl ester | at pH 7.6 and 25°C | Homo sapiens | |
0.061 | - |
11-hydroxy-DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens | |
0.0779 | - |
cannabidiol | at pH 7.6 and 25°C | Homo sapiens | |
0.081 | - |
prostaglandin F2alpha | at pH 7.6 and 25°C | Homo sapiens | |
0.128 | - |
prostaglandin E2 | at pH 7.6 and 25°C | Homo sapiens | |
0.175 | - |
DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme has dual functional roles as a prostaglandin D2-synthesizing enzyme and as an extracellular transporter for diverse lipophilic compounds in the cerebrospinal fluid | Homo sapiens |