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Literature summary for 5.3.99.2 extracted from
- Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds (2015), Chem. Biol. Interact., 229, 91-99 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli XL-1 Blue cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anthralin | i.e. 1,8-dihydroxyanthracen-9(10H)-one | Homo sapiens |  |
| bithionate sodium | - |
Homo sapiens | |
| bromocriptine mesylate | - |
Homo sapiens | |
| candesartan cilextil | - |
Homo sapiens | |
| chlorophyllide copper complex sodium salt | linear competitive inhibitor | Homo sapiens | |
| deoxycorticosterone acetate | - |
Homo sapiens | |
| epirubicin hydrochloride | - |
Homo sapiens | |
| erythrosine sodium | i.e. disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate | Homo sapiens | |
| Ethacrynic acid | i.e. [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | Homo sapiens | |
| fluorescein | - |
Homo sapiens | |
| Hexachlorophene | - |
Homo sapiens | |
| iopanic acid | linear competitive inhibitor, i.e. 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid | Homo sapiens | |
| Ketoprofen | i.e. [3-(3-hydroxybut-3-en-2-yl)phenyl](phenyl)methanone | Homo sapiens | |
| merbromin | - |
Homo sapiens | |
| montelukast sodium | - |
Homo sapiens | |
| nisoldipine | - |
Homo sapiens | |
| pararosaniline pamoate | - |
Homo sapiens | |
| pyrvinium pamoate | - |
Homo sapiens | |
| sanguinarine sulfate | linear competitive inhibitor | Homo sapiens | |
| sennoside A | - |
Homo sapiens | |
| suramin | - |
Homo sapiens | |
| Tannic acid | nonlinear competitive inhibitor | Homo sapiens | |
| tranilast | i.e. 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | Homo sapiens | - |
Prostaglandin D2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60760 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-IMAC chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-chloro-2,4-dinitrobenzene + glutathione | - |
Homo sapiens | ? | - |
? | |
| 1-fluoro-2,4-dinitrobenzene + glutathione | - |
Homo sapiens | ? | - |
? | |
| allyl isothiocyanate + glutathione | - |
Homo sapiens | ? | - |
? | |
| benzyl isothiocyanate + glutathione | - |
Homo sapiens | ? | - |
? | |
| cyclohexyl isothiocyanate + glutathione | - |
Homo sapiens | ? | - |
? | |
| phenethyl isothiocyanate + glutathione | - |
Homo sapiens | ? | - |
? | |
| propyl isothiocyanate + glutathione | - |
Homo sapiens | ? | - |
? | |
| Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hematopoietic prostaglandin D2 synthase | - |
Homo sapiens |
| HPGDS | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
suramin | at pH 6.5 and 30°C | Homo sapiens | |
| 0.0002 | - |
Tannic acid | at pH 6.5 and 30°C | Homo sapiens | |
| 0.001 | - |
sanguinarine sulfate | at pH 6.5 and 30°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
at pH 6.5 and 30°C | Homo sapiens | erythrosine sodium | |
| 0.0003 | - |
at pH 6.5 and 30°C | Homo sapiens | suramin | |
| 0.0004 | - |
at pH 6.5 and 30°C | Homo sapiens | Tannic acid | |
| 0.0006 | - |
at pH 6.5 and 30°C | Homo sapiens | sanguinarine sulfate | |
| 0.0017 | - |
at pH 6.5 and 30°C | Homo sapiens | chlorophyllide copper complex sodium salt | |
| 0.0018 | - |
at pH 6.5 and 30°C | Homo sapiens | iopanic acid | |
| 0.002 | - |
at pH 6.5 and 30°C | Homo sapiens | montelukast sodium | |
| 0.0033 | - |
at pH 6.5 and 30°C | Homo sapiens | merbromin | |
| 0.0055 | - |
at pH 6.5 and 30°C | Homo sapiens | candesartan cilextil | |
| 0.0084 | - |
at pH 6.5 and 30°C | Homo sapiens | epirubicin hydrochloride | |
| 0.0086 | - |
at pH 6.5 and 30°C | Homo sapiens | deoxycorticosterone acetate | |
| 0.0089 | - |
at pH 6.5 and 30°C | Homo sapiens | Hexachlorophene | |
| 0.012 | - |
at pH 6.5 and 30°C | Homo sapiens | bithionate sodium | |
| 0.0132 | - |
at pH 6.5 and 30°C | Homo sapiens | bromocriptine mesylate | |
| 0.0134 | - |
at pH 6.5 and 30°C | Homo sapiens | fluorescein | |
| 0.0137 | - |
at pH 6.5 and 30°C | Homo sapiens | tranilast | |
| 0.0172 | - |
at pH 6.5 and 30°C | Homo sapiens | pyrvinium pamoate | |
| 0.0203 | - |
at pH 6.5 and 30°C | Homo sapiens | Ketoprofen | |
| 0.0208 | - |
at pH 6.5 and 30°C | Homo sapiens | pararosaniline pamoate | |
| 0.0237 | - |
at pH 6.5 and 30°C | Homo sapiens | anthralin | |
| 0.029 | - |
at pH 6.5 and 30°C | Homo sapiens | nisoldipine | |
| 0.0393 | - |
at pH 6.5 and 30°C | Homo sapiens | sennoside A | |
| 0.044 | - |
at pH 6.5 and 30°C | Homo sapiens | Ethacrynic acid | |
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