Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of double knock out mice lacking lipocalin prostaglandin D synthase and PPARgamma2 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules | ? | - |
? | |
additional information | Mus musculus C57BL/6 | the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male | - |
Mus musculus C57BL/6 | - |
male | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
epididymis | - |
Mus musculus | - |
white adipose tissue | e.g. epididymal | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules | Mus musculus | ? | - |
? | |
additional information | the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-PGDS | - |
Mus musculus |
lipocalin prostaglandin D synthase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | mice lacking PPARgamma2 have elevated levels of lipocalin prostaglandin D synthase expression in brown adipose tissue and subcutaneous white adipose tissue | up |
General Information | Comment | Organism |
---|---|---|
malfunction | double knockout mice, lacking lipocalin prostaglandin D synthase as well as PPARgamma2, have impaired carbohydrate and lipid metabolism with glucose tolerance compared to any other genotypes, their interscapular brown adipose tissue exhibits greater lipid content than that of wild-type mice, which is independent of PPARgamma2 dysfunction. In subcutaneous white adipose tissue, L-PGDS KO mice exhibit a 4fold increase in UCP1 expression and a reduction in adipogenic marker aP2 expression. Phenotypes, overview | Mus musculus |
physiological function | requirement of the enzyme for maintenance of subcutaneous white adipose tissue function. The enzyme and peroxisome proliferator-activated receptor gamma2 coordinate to regulate carbohydrate and lipid metabolism | Mus musculus |