Activating Compound | Comment | Organism | Structure |
---|---|---|---|
arrestin-3 | arrestin-3 promotes prostaglandin D2 production by L-PGDS in vitro. Incubation of L-PGDS with arrestin-3 amino acids 56-100 enhances prostaglandin D2 production by 145% | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli C41(DE3) cells | Mus musculus |
expressed in Escherichia coli C41(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SeCl4 | - |
Homo sapiens | |
SeCl4 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | perinuclear L-type prostaglandin synthase/arrestin-3 co-localization is observed in prostaglandin D2-producing MG-63 cells | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
SDS-PAGE | Mus musculus |
25000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography | Mus musculus |
Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | - |
Mus musculus | - |
MG-63 cell | - |
Homo sapiens | - |
osteoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin D2 | - |
? | |
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-PGDS | also called beta-trace | Mus musculus |
L-PGDS | also called beta-trace | Homo sapiens |
L-prostaglandin D synthase | - |
Mus musculus |
L-prostaglandin D synthase | - |
Homo sapiens |
L-type prostaglandin synthase | - |
Mus musculus |
L-type prostaglandin synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | L-PGDS is glutathione-independent | Mus musculus | |
additional information | L-PGDS is glutathione-independent | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | co-localization of arrestin-3 with L-PGDS is drastically reduced in MG-63 cells when L-PGDS activity is inhibited | Homo sapiens |