Literature summary for 5.3.99.2 extracted from

Hohwy, M.; Spadola, L.; Lundquist, B.; Hawtin, P.; Dahmen, J.; Groth-Clausen, I.; Nilsson, E.; Persdotter, S.; von Wachenfeldt, K.; Folmer, R.H.; Edman, K.
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design (2008), J. Med. Chem., 51, 2178-2186.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole	inhibitor generated by fragment-based drug design, crystallographic data	Homo sapiens
3-phenyl-5-(1H-pyrazol-3-yl)-1,2-oxazole	-	Homo sapiens
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid	-	Homo sapiens
N-[4-methyl-3-[([3-[(4-methylpiperazin-1-yl)methyl]phenyl]carbonyl)amino]phenyl]-3-phenylisothiazole-5-carboxamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60760	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LAD-2 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000021	-	37°C	Homo sapiens	2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole
0.000075	-	37°C	Homo sapiens	N-[4-methyl-3-[([3-[(4-methylpiperazin-1-yl)methyl]phenyl]carbonyl)amino]phenyl]-3-phenylisothiazole-5-carboxamide
0.000138	-	37°C	Homo sapiens	4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
0.00092	-	37°C	Homo sapiens	3-phenyl-5-(1H-pyrazol-3-yl)-1,2-oxazole

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Release 2023.1 (January 2023)