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Literature summary for 5.3.99.2 extracted from

  • Mohri, I.; Taniike, M.; Okazaki, I.; Kagitani-Shimono, K.; Aritake, K.; Kanekiyo, T.; Yagi, T.; Takikita, S.; Kim, H.S.; Urade, Y.; Suzuki, K.
    Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides (2006), J. Neurochem., 97, 641-651.
    View publication on PubMed
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Application

Application Comment Organism
medicine enzyme mRNA is up-regulated in mouse model of globoid cell leukodystrophy or Krabbe’s disease, of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease,. Oligodendrocytes of all these mouse models show strong immunoreactivity for enzyme, but not astrocytes or microglia Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme may play a role in scavenging harmful lipophilic substrates in lysosomal storage disorders ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 mouse model of globoid cell leukodystrophy or Krabbe’s disease, of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease
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Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme mRNA is up-regulated in mouse model of globoid cell leukodystrophy or Krabbe’s disease, of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease,. Oligodendrocytes of all these mouse models show strong immunoreactivity for enzyme, but not astrocytes or microglia Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme may play a role in scavenging harmful lipophilic substrates in lysosomal storage disorders Mus musculus ?
-
 ?