Literature summary for 5.3.99.2 extracted from

Park, J.M.; Kanaoka, Y.; Eguchi, N.; Aritake, K.; Grujic, S.; Materi, A.M.; Buslon, V.S.; Tippin, B.L.; Kwong, A.M.; Salido, E.; French, S.W.; Urade, Y.; Lin, H.J.
Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice (2007), Cancer Res., 67, 881-889.

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Application

Application	Comment	Organism
medicine	hematopoitic prostaglandin synthase controls an inhibitory effect on intestinal tumours	Mus musculus
medicine	hematopoitic prostaglandin synthase controls an inhibitory effect on intestinal tumours	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	disruption of gene for hematopoietic prostaglandin synthase in ApcMin/+ mice bearing a defect in the adenomatous polyposis coli gene which leads to development of many adenomas leads to 50% more intestinal adenomas compared with controls. Tumour size is not affected	Mus musculus
additional information	transgenic expression of hematopoitic prostaglandin synthase in ApcMin/+ mice have 80% fewer intestinal adenomas	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-
Mus musculus	-	ApcMin/+ mice bearing a defect in the adenomatous polyposis coli gene which leads to development of many adenomas	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gut mucosa	-	Mus musculus	-
macrophage	of gut mucosa	Mus musculus	-
monocyte	of gut mucosa	Mus musculus	-

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Release 2023.1 (January 2023)