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Literature summary for 5.3.4.1 extracted from

  • Perri, E.R.; Thomas, C.J.; Parakh, S.; Spencer, D.M.; Atkin, J.D.
    The unfolded protein response and the role of protein disulfide isomerase in neurodegeneration (2015), Front. Cell Dev. Biol., 3, 80 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
S-nitrosylation
-
 Homo sapiens

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ERp57
-
 Homo sapiens
ERp72
-
 Homo sapiens
PDI
-
 Homo sapiens
protein disulfide isomerase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is induced during endoplasmic reticulum stress. The enzyme levels are markedly increased in Alzheimer's disease, Parkinson's disease, amyotropic lateral sclerosis and other neurodegenerative diseases up

General Information

General Information Comment Organism
metabolism the enzyme is responsible for the oxidation (formation), reduction (break down) and isomerization (rearrangement) of protein disulfide bonds via disulfide interchange activity. The enzyme also has general chaperone activity Homo sapiens