Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mesocricetus auratus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Mesocricetus auratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Insulin-(SS) + GSH | Mesocricetus auratus | - |
Insulin-(SH)2 + GSSG | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Insulin-(SS) + GSH | - |
Mesocricetus auratus | Insulin-(SH)2 + GSSG | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Mesocricetus auratus |
Synonyms | Comment | Organism |
---|---|---|
DsbA | - |
Mesocricetus auratus |
Erp | - |
Mesocricetus auratus |
PDI | - |
Mesocricetus auratus |
protein disulfide isomerase | - |
Mesocricetus auratus |
Organism | Comment | Expression |
---|---|---|
Mesocricetus auratus | the enzyme is upregulated in prion disease | up |
General Information | Comment | Organism |
---|---|---|
physiological function | protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and prion protein mutant-induced cytotoxicity. The enzyme functions as a pleiotropic regulator in the processes of different misfolded prion proteins and at different stages during prion infection. The enzyme is involved in mitochondrial dysfunction induced by misfolded prion | Mesocricetus auratus |