Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q11067 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PDIA6 | - |
Caenorhabditis elegans |
protein disulfide isomerase A6 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
malfunction | PDIA6-deficient cells hyperrespond to endoplasmic reticulum stress with sustained autophosphorylation of inositol-requiring enzyme 1alpha and splicing of XBP1 mRNA, resulting in exaggerated upregulation of UPR target genes and increased apoptosis. In vivo, PDIA6-deficient Caenorhabditis elegans exhibits constitutive unfolded protein response and fails to complete larval development | Caenorhabditis elegans |
physiological function | isoform PDIA6 limits the duration of inositol-requiring enzyme 1alpha (IRE1alpha) activity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE1 is activated | Caenorhabditis elegans |