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Literature summary for 5.3.4.1 extracted from

  • Jessop, C.E.; Watkins, R.H.; Simmons, J.J.; Tasab, M.; Bulleid, N.J.
    Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins (2009), J. Cell Sci., 122, 4287-4295.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
PDI, expression of substrate-trapping mutants of PDI family members ERp46, ERp18, ERp57, ERp72, and P5 in HT-1080 cells, the mutant enzymes form mixed disulfides Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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Homo sapiens 5783
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDI forms mixed disulfides in substrate molecules, substrates are Ero1alpha, clusterin, or PTX3, analysis of PDI substrate specificity, comparison to other members of the protein disulfide isomerase family of oxidoreductases, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
More the enzyme is a member of the protein disulfide isomerase family of oxidoreductases Homo sapiens
Protein disulphide isomerase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin the enzymes PDI, P5, ERp72, ERp46 and ERp18 contains a thioredoxin binding site and the CGHC active site Homo sapiens