Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of CxPR2 activity by treatment with cysteine and serine protease inhibitors E-64 and DCI | Mus musculus | |
additional information | CxRP2 activity is partially depleted by immobilized RNK-16 granule proteins, no inhibition of CxPR2 activity by treatment with cysteine and serine protease inhibitors E-64 and DCI | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytotoxic granule | - |
Rattus norvegicus | - |
- |
cytotoxic granule | - |
Mus musculus | - |
- |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect by Ca2+ | Rattus norvegicus | |
additional information | no effect by Ca2+ | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | ? | - |
? | |
additional information | Mus musculus | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | ? | - |
? | |
additional information | Mus musculus C57BL/6 | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P27773 | PDIA3; C57BL/6 mice | - |
Mus musculus C57BL/6 | P27773 | PDIA3; C57BL/6 mice | - |
Rattus norvegicus | - |
Fischer 344 rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RNK-16 cell | an NK cell-like leukemia cell line | Rattus norvegicus | - |
T-lymphocyte | - |
Rattus norvegicus | - |
T-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | Rattus norvegicus | ? | - |
? | |
additional information | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | Mus musculus | ? | - |
? | |
additional information | PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein disulfide isomerase | - |
Rattus norvegicus |
protein disulfide isomerase | - |
Mus musculus |
protein disulfide isomerase A1 | - |
Rattus norvegicus |
protein disulfide isomerase A3 | - |
Rattus norvegicus |
protein disulfide isomerase A3 | - |
Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
70 | 75 | CxRP2 is heat sensitive losing substantial activity after 30 min at 70-75 °C, overview | Rattus norvegicus |
70 | 75 | CxRP2 is heat sensitive losing substantial activity after 30 min at 70-75°C, overview | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
7.5 | - |
assay at | Mus musculus |