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Literature summary for 5.3.4.1 extracted from
- Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines (2010), Biotechnol. Bioeng., 105, 770-779.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| PDI, quantitative expression analysis, overexpression in CHO and in NS0/2N2 cells | Mus musculus |
| PDI, quantitative expression analysis, overexpression in CHO cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | PDI gene silencing in NS0/2N2 cells by transfection with two different PDI siRNAs, PDI1 and PDI2, respectively. Transiently silencing PDI mRNA in NS0/2N2 cells and increasing the intracellular levels of members of the PDI family, PDI, ERp72, and PDIp, have an effect on the mRNA levels, assembly and secretion of an IgG4 isotype, overview | Mus musculus |
| additional information | transiently silencing PDI mRNA and increasing the intracellular levels of members of the PDI family, PDI, ERp72, and PDIp, have an effect on the mRNA levels, assembly and secretion of an IgG4 isotype, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| NS0 cell | - |
Mus musculus | - |
| NS0 cell | NS0/40 cell | Mus musculus | - |
| NS0 cell | NS0/2N2 cell | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme is a member of the PDI family | Mus musculus |
| More | the enzyme is a member of the PDI family | Homo sapiens |
| PDI | - |
Mus musculus |
| PDI | - |
Homo sapiens |
| protein disulfide isomerase | - |
Mus musculus |
| protein disulfide isomerase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a role in the formation of disulfide bonds in immunoglobulins, it is also involved in disulfide bond formation of the IgG4 subclass of antibody, but catalysis of disulfide bond formation is not rate limiting for IgG4 production | Mus musculus |
| physiological function | the enzyme plays a role in the formation of disulfide bonds in immunoglobulins, it is also involved in disulfide bond formation of the IgG4 subclass of antibody, but catalysis of disulfide bond formation is not rate limiting for IgG4 production | Homo sapiens |
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Release 2023.1 (January 2023)
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