Cloned (Comment) | Organism |
---|---|
wild-type and/or mutant PDI overexpression in vascular smooth muscle cells and in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | wild-type PDI or PDI mutated in all four redox cysteines overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression, with 2.5fold enhanced basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA, phenotype, overview. Knockdown of PDI leads to Nox1 mRNA and protein downregulation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-nitrosocysteine | S-nitrosates endogenous or overexpressed PDI in HEK-293T cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Homo sapiens |
protein disulfide isomerase | - |
Homo sapiens |