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Literature summary for 5.3.4.1 extracted from

  • Fernandes, D.C.; Manoel, A.H.; Wosniak, J.; Laurindo, F.R.
    Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: effects of nitrosothiol exposure (2009), Arch. Biochem. Biophys., 484, 197-204.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and/or mutant PDI overexpression in vascular smooth muscle cells and in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information wild-type PDI or PDI mutated in all four redox cysteines overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression, with 2.5fold enhanced basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA, phenotype, overview. Knockdown of PDI leads to Nox1 mRNA and protein downregulation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-nitrosocysteine S-nitrosates endogenous or overexpressed PDI in HEK-293T cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDI
-
Homo sapiens
protein disulfide isomerase
-
Homo sapiens