Literature summary for 5.3.4.1 extracted from

Zhou, M.; Jacob, A.; Ho, N.; Miksa, M.; Wu, R.; Maitra, S.R.; Wang, P.
Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release (2008), Crit. Care Med., 12, R100.

Search for more literature for 5.3.4.1

Application

Application	Comment	Organism
medicine	lipopolysaccharide decreases protein disulfide isomerase protein expression by 33% in RAW 264.7 cells. Incubation of the cells with bacitracin significantly decreases tumor necrosis factor alpha gene expression and release. Downregulation of protein disulfide isomerase gene expression by siRNA correlates with a 3.2fold increase in tumor necrosis factor alpha release into the cell supernatant	Mus musculus
medicine	protein disulfide gene expression is significantly decreased by 28% and 69% at 20 h after cecal ligation and puncture or lipopolysaccharide infusion, respectively	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	downregulation of protein disulfide isomerase gene expression by siRNA leads to an average 36.8% inhibition of gene expression and correlates with a 3.2fold increase in tumor necrosis factor alpha release into the cell supernatant	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

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Release 2023.1 (January 2023)