Protein Variants | Comment | Organism |
---|---|---|
F449R | mutation in the last alpha helix of domain a', 7.5-8fold reduced appearance rate of folding product RNase A | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Ovis aries | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
unfolded RNase A | reduced and denatured bovine pancreatic RNase A, glutathione redox buffer, PDI catalyzes the entire RNase A folding by enhancing the formation and reduction of mixed disulfides with glutathione and the formation of intramolecular disulfides | Homo sapiens | refolded RNase A | - |
? | |
unfolded RNase A | tyrosine and tryptophane residues in peptides are the recognition motifs for their binding | Ovis aries | refolded RNase A | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PDI consist of 2 catalytically active domains, a and a', and two inactive ones b and b', all four domains have a thioredoxin fold, domain b' contains he primary peptide binding site | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Homo sapiens |
PDIp | - |
Ovis aries |