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Literature summary for 5.3.4.1 extracted from
- Protein disulphide isomerase: building bridges in protein folding (1994), Trends Biochem. Sci., 19, 331-336.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | - |
? | - |
? |  |
| additional information | eukaryota | PDI is a subunit of the enzyme prolyl-4-hydroxylase, which catalyzes the formation of 4-hydroxyprolyl residues in nascent collagen-like polypeptides. PDI is also a subunit of a triacylglycerol transfer protein, which facilitates the incorporation of lipids into newly synthesized core lipoproteins within the endoplasmic reticulum. The function of PDI is to maintain the alpha-subunit of this enzyme in an active form | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | the enzyme has an essential role that is distinct from its function in formation of native disulphides | ? | - |
? | |
| Proteins | eukaryota | native, reduced or with wrong disulfide bonds | ? | - |
? | |
| Proteins | Homo sapiens | native, reduced or with wrong disulfide bonds | ? | - |
? | |
| Proteins | Rattus norvegicus | native, reduced or with wrong disulfide bonds | ? | - |
? | |
| Proteins | Bos taurus | native, reduced or with wrong disulfide bonds | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteria | - |
- |
- |
| Bos taurus | - |
- |
- |
| eukaryota | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Trypanosoma brucei | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Bos taurus | ? | - |
? | |
| additional information | PDI is a subunit of the enzyme prolyl-4-hydroxylase, which catalyzes the formation of 4-hydroxyprolyl residues in nascent collagen-like polypeptides. PDI is also a subunit of a triacylglycerol transfer protein, which facilitates the incorporation of lipids into newly synthesized core lipoproteins within the endoplasmic reticulum. The function of PDI is to maintain the alpha-subunit of this enzyme in an active form | eukaryota | ? | - |
? | |
| additional information | the enzyme has an essential role that is distinct from its function in formation of native disulphides | Saccharomyces cerevisiae | ? | - |
? | |
| Proteins | - |
Gallus gallus | Proteins | - |
? | |
| Proteins | - |
Bacteria | Proteins | - |
? | |
| Proteins | - |
eukaryota | Proteins | - |
? | |
| Proteins | - |
Homo sapiens | Proteins | - |
? | |
| Proteins | - |
Rattus norvegicus | Proteins | - |
? | |
| Proteins | - |
Saccharomyces cerevisiae | Proteins | - |
? | |
| Proteins | - |
Bos taurus | Proteins | - |
? | |
| Proteins | - |
Oryctolagus cuniculus | Proteins | - |
? | |
| Proteins | - |
Trypanosoma brucei | Proteins | - |
? | |
| Proteins | native, reduced or with wrong disulfide bonds | eukaryota | ? | - |
? | |
| Proteins | native, reduced or with wrong disulfide bonds | Homo sapiens | ? | - |
? | |
| Proteins | native, reduced or with wrong disulfide bonds | Rattus norvegicus | ? | - |
? | |
| Proteins | native, reduced or with wrong disulfide bonds | Bos taurus | ? | - |
? | |
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