Application | Comment | Organism |
---|---|---|
synthesis | useful in facilitating the in vitro folding of proteins | Bacteria |
synthesis | useful in facilitating the in vitro folding of proteins | eukaryota |
Protein Variants | Comment | Organism |
---|---|---|
C35S | mutagenesis of Cys35 or Cys379 to a Ser causes loss of activity | Rattus norvegicus |
C379S | mutagenesis of Cys35 or Cys379 to a Ser causes loss of activity | Rattus norvegicus |
C55S/C379S | The double active site mutant Cys55Ser, Cys379Ser is not capable of catalyzing protein folding | Rattus norvegicus |
G36A | Mutagenesis of Trp34 to Ser and Gly36 to Ala has little effect on activity. Mutagenesis of amino acid residues within the active site sequence, Trp34 to a Ser and Gly36 to an Ala has little effect on activity | Rattus norvegicus |
H37P | Mutagenesis of His37 to a Pro causes almost complete loss of activity | Rattus norvegicus |
L39R | Mutagenesis of Lys39 to an Arg results in only a modest loss of activity | Rattus norvegicus |
W34S | Mutagenesis of Trp34 to Ser and Gly36 to Ala has little effect on activity. Mutagenesis of amino acid residues within the active site sequence, Trp34 to a Ser and Gly36 to an Ala has little effect on activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
endoplasmic reticulum | lumen | eukaryota | 5783 | - |
endoplasmic reticulum | lumen | Rattus norvegicus | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | eukaryota | the enzyme acts as a thyroid-hormone binding protein | ? | - |
? | |
Proteins | Bacteria | - |
? | - |
? | |
Proteins | Rattus norvegicus | - |
? | - |
? | |
Proteins | eukaryota | facilitates the formation of disulfides during the folding and processing of membrane and secretory proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteria | - |
- |
- |
eukaryota | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
catalyses the rearrangement of -S-S- bonds in proteins | mechanism | eukaryota | |
catalyses the rearrangement of -S-S- bonds in proteins | mechanism | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme acts as a thyroid-hormone binding protein | eukaryota | ? | - |
? | |
Proteins | native, reduced or with wrong disulfide bonds | Bacteria | Proteins | with correct disulfide bonds | ? | |
Proteins | native, reduced or with wrong disulfide bonds | eukaryota | Proteins | with correct disulfide bonds | ? | |
Proteins | native, reduced or with wrong disulfide bonds | Rattus norvegicus | Proteins | with correct disulfide bonds | ? | |
Proteins | native, reduced or with wrong disulfide bonds | Saccharomyces cerevisiae | Proteins | with correct disulfide bonds | ? | |
Proteins | - |
Bacteria | ? | - |
? | |
Proteins | - |
Rattus norvegicus | ? | - |
? | |
Proteins | facilitates the formation of disulfides during the folding and processing of membrane and secretory proteins | eukaryota | ? | - |
? |