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Literature summary for 5.3.3.9 extracted from

  • Polet, H.; Levine, L.
    Metabolism of prostaglandins E, A, and C in serum (1975), J. Biol. Chem., 250, 351-357.
    View publication on PubMed

General Stability

General Stability Organism
loss of activity after pepsin digestion Homo sapiens
loss of activity after pepsin digestion Rattus norvegicus
loss of activity after pepsin digestion Oryctolagus cuniculus
10% loss of activity after dialysis Homo sapiens
10% loss of activity after dialysis Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Homo sapiens
5,5'-dithiobis(2-nitrobenzoate)
-
Oryctolagus cuniculus
5,5'-dithiobis(2-nitrobenzoate)
-
Rattus norvegicus
iodoacetate
-
Homo sapiens
iodoacetate
-
Oryctolagus cuniculus
NEM
-
Homo sapiens
NEM
-
Oryctolagus cuniculus
NEM
-
Rattus norvegicus
p-mercuribenzoate
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Oryctolagus cuniculus
-
-
-
Felis catus
-
-
-
Ovis aries
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
no activity in Bos taurus
-
ox
-
no activity in Gallus gallus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Mus musculus
-
serum
-
Homo sapiens
-
serum
-
Rattus norvegicus
-
serum
-
Oryctolagus cuniculus
-
serum
-
Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Cavia porcellus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Mus musculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Rattus norvegicus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Sus scrofa (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Ovis aries (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Canis lupus familiaris (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Homo sapiens (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Oryctolagus cuniculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Felis catus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
-
Rattus norvegicus
70
-
-
Felis catus
70
-
20 min, 50-75% loss of activity Oryctolagus cuniculus
70
-
20 min, 93% loss of activity Homo sapiens