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Literature summary for 5.3.3.9 extracted from

  • Jones, R.L.; Cammock, S.; Horton, E.W.
    Partial purification and properties of cat plasma prostaglanin A isomerase (1972), Biochim. Biophys. Acta, 280, 588-601.
    View publication on PubMed
Search for more literature for 5.3.3.9

Inhibitors

Inhibitors Comment Organism Structure
13,14-Dihydroprostaglandin A1
-
 Felis catus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 prostaglandin A1
-
 Felis catus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Felis catus
-
-
-
no activity in Bos taurus
-
 ox
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Felis catus

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Rattus norvegicus
-
blood plasma
-
 Sus scrofa
-
blood plasma
-
 Oryctolagus cuniculus
-
blood plasma
-
 Canis lupus familiaris
-
blood plasma
-
 Felis catus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Rattus norvegicus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Sus scrofa (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Canis lupus familiaris (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Oryctolagus cuniculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Felis catus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid i.e. prostaglandin A2 Oryctolagus cuniculus ?
-
 ?
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid i.e. prostaglandin A2 Felis catus ?
-
 ?
15-Epiprostaglandin A2
-
 Oryctolagus cuniculus ?
-
 ?
15-Epiprostaglandin A2
-
 Felis catus ?
-
 ?
19-Hydroxyprostaglandin A1
-
 Felis catus ?
-
 ?
prostaglandin A1
-
 Felis catus ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 10 min, denaturation commences above 50°C Felis catus
62
-
 10 min, complete inactivation Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 9
-
 Oryctolagus cuniculus
8 9
-
 Felis catus

pH Range

pH Minimum pH Maximum Comment Organism
6 10 pH 6.0: about 30% of maximal activity, pH 10.0: about 35% of maximal activity Felis catus