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Literature summary for 5.3.3.9 extracted from

  • Polet, H.; Levine, L.
    Serum prostaglandin A1 isomerase (1971), Biochem. Biophys. Res. Commun., 45, 1169-1176.
    View publication on PubMed

General Stability

General Stability Organism
loss of activity after pepsin digestion Homo sapiens
loss of activity after pepsin digestion Rattus norvegicus
loss of activity after pepsin digestion Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Homo sapiens
5,5'-dithiobis(2-nitrobenzoate)
-
Oryctolagus cuniculus
5,5'-dithiobis(2-nitrobenzoate)
-
Rattus norvegicus
NEM
-
Homo sapiens
NEM
-
Oryctolagus cuniculus
NEM
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Equus caballus
-
weak activity
-
Felis catus
-
-
-
Homo sapiens
-
weak activity
-
Platyrrhini
-
weak activity
-
Mus musculus
-
-
-
no activity in Bos taurus
-
fetal calf
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Mus musculus
-
serum
-
Homo sapiens
-
serum
-
Rattus norvegicus
-
serum
-
Oryctolagus cuniculus
-
serum
-
Felis catus
-
serum
-
Platyrrhini
-
serum
-
Equus caballus
-
blood plasma
-
Rattus norvegicus
-
blood plasma
-
Oryctolagus cuniculus
-
blood plasma
-
Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Mus musculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Homo sapiens (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Platyrrhini (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Equus caballus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Rattus norvegicus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid i.e. prostaglandin B1 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Oryctolagus cuniculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid i.e. prostaglandin B1 ?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Felis catus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid i.e. prostaglandin B1 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
-
Homo sapiens
70
-
20 min, enzyme activity in serum is stable Rattus norvegicus
70
-
20 min, enzyme activity in serum is stable Oryctolagus cuniculus
70
-
20 min, enzyme activity in serum is stable Felis catus
60
-
3 h, enzyme activity in plasma is stable Rattus norvegicus
60
-
3 h, enzyme activity in plasma is stable Oryctolagus cuniculus
60
-
3 h, enzyme activity in plasma is stable Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5 10
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 10 pH 6.5: about 35% of maximal activity, pH 9.5-10.0: maximal activity Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
2
-
4°C, 15 h, enzyme activity in serum is stable Rattus norvegicus
2
-
4°C, 15 h, enzyme activity in serum is stable Oryctolagus cuniculus