Application | Comment | Organism |
---|---|---|
medicine | decreased levels of 2,3-trans-enoyl-CoA isomerase might have impact on the aberrant behaviour of cancer cells | Homo sapiens |
medicine | in primary cultures of epithelial cells from 23 breast cancer tissue samples, nucleophosmin is increased in the group with metastases. The levels of 2,3-trans-enoyl-CoA isomerase and glutathione peroxidase 1 are decreased | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
determined by 2-D gel electrophoresis | Homo sapiens |
28000 | - |
theoretical | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P42126 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
breast carcinoma cell | - |
Homo sapiens | - |
epithelium | primary cultures of epithelial cells from breast cancer tissue samples | Homo sapiens | - |
mammary epithelial cell | - |
Homo sapiens | - |
primary culture | primary cultures of epithelial cells from breast cancer tissue samples | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 27000, SDS-PAGE | Homo sapiens |
? | x * 28000, estimated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
2,3-trans-enoyl-CoA isomerase | - |
Homo sapiens |
3,2-trans-Enoyl-CoA isomerase | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | estimated from amino acid sequence | - |
6 |
Homo sapiens | theoretical | - |
6 |
Homo sapiens | isoelectric focusing | - |
6.3 |
Homo sapiens | determined by 2-D gel electrophoresis | - |
6.3 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of 2,3-trans-enoyl-CoA isomerase is decreased in metastatic tumor tissue | down |
Homo sapiens | the level of 2,3-trans-enoyl-CoA isomerase is decreased in metastatic breast cancer | down |
General Information | Comment | Organism |
---|---|---|
physiological function | 2,3-trans-enoyl-CoA isomerase is involved in mitochondrial beta-oxidation of unsaturated fatty acids | Homo sapiens |
physiological function | the enzyme is involved in mitochondrial beta-oxidation of unsaturated fatty acids | Homo sapiens |