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Literature summary for 5.3.3.8 extracted from

  • Ren, Y.; Aguirre, J.; Ntamack, A.G.; Chu, C.; Schulz, H.
    An alternative pathway of oleate beta-oxidation in Escherichia coli involving the hydrolysis of a dead end intermediate by a thioesterase (2004), J. Biol. Chem., 279, 11042-11050.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium. ?
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 ?
additional information Escherichia coli B / ATCC 11303 oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium. ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Escherichia coli B / ATCC 11303
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans,5-cis-tetradecadienoyl-CoA
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 Escherichia coli 3,5-cis-tetradecadienoyl-CoA
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 ?
2-trans,5-cis-tetradecadienoyl-CoA
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 Escherichia coli B / ATCC 11303 3,5-cis-tetradecadienoyl-CoA
-
 ?
additional information oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium. Escherichia coli ?
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 ?
additional information oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium. Escherichia coli B / ATCC 11303 ?
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 ?

Synonyms

Synonyms Comment Organism
DELTA3,DELTA2-enoyl-CoA isomerase
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 Escherichia coli