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Literature summary for 5.3.3.5 extracted from

  • Koenig, M.; Mueller, C.; Bracher, F.
    Stereoselective synthesis of a new class of potent and selective inhibitors of human DELTA8,7-sterol isomerase (2013), Bioorg. Med. Chem., 21, 1925-1943.
    View publication on PubMed
Search for more literature for 5.3.3.5

Inhibitors

Inhibitors Comment Organism Structure
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-(pent-4-en-1-ylamino)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-(pent-4-en-1-ylamino)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-(pent-4-en-1-ylamino)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-(pent-4-en-1-ylamino)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-[methyl(pent-4-en-1-yl)amino]octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-[methyl(pent-4-en-1-yl)amino]octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-[methyl(pent-4-en-1-yl)amino]octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)-5-[methyl(pent-4-en-1-yl)amino]octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-5-(benzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-5-(benzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-5-(benzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-5-(benzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-5-(dibenzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-5-(dibenzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-5-(dibenzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-5-(dibenzylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-5-amino-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-5-amino-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-5-amino-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-5-amino-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-5-[benzyl(methyl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-5-[benzyl(methyl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-5-[benzyl(methyl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-5-[benzyl(methyl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,4R,5S,7aR)-5-[benzyl(pent-4-en-1-yl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,4R,5S,7aR)-5-[benzyl(pent-4-en-1-yl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,4R,5S,7aR)-5-[benzyl(pent-4-en-1-yl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,4R,5S,7aR)-5-[benzyl(pent-4-en-1-yl)amino]-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
(1R,3aR,5S,7aR)-5-(dimethylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 [Candida] glabrata
(1R,3aR,5S,7aR)-5-(dimethylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Homo sapiens
(1R,3aR,5S,7aR)-5-(dimethylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Saccharomyces cerevisiae
(1R,3aR,5S,7aR)-5-(dimethylamino)-3a,7a-dimethyl-1-(6-methylheptan-2-yl)octahydro-1H-inden-4-ol
-
 Yarrowia lipolytica
AY9944
-
 [Candida] glabrata
AY9944
-
 Homo sapiens
AY9944
-
 Saccharomyces cerevisiae
AY9944
-
 Yarrowia lipolytica
fenpropimorph
-
 [Candida] glabrata
fenpropimorph
-
 Homo sapiens
fenpropimorph
-
 Saccharomyces cerevisiae
fenpropimorph
-
 Yarrowia lipolytica
ifenprodil
-
 [Candida] glabrata
ifenprodil
-
 Homo sapiens
ifenprodil
-
 Saccharomyces cerevisiae
ifenprodil
-
 Yarrowia lipolytica
MDL28815
-
 [Candida] glabrata
MDL28815
-
 Homo sapiens
MDL28815
-
 Saccharomyces cerevisiae
MDL28815
-
 Yarrowia lipolytica
tamoxifen
-
 [Candida] glabrata
tamoxifen
-
 Homo sapiens
tamoxifen
-
 Saccharomyces cerevisiae
tamoxifen
-
 Yarrowia lipolytica
Trifluoperazine
-
 [Candida] glabrata
Trifluoperazine
-
 Homo sapiens
Trifluoperazine
-
 Saccharomyces cerevisiae
Trifluoperazine
-
 Yarrowia lipolytica
trifluperidol
-
 [Candida] glabrata
trifluperidol
-
 Homo sapiens
trifluperidol
-
 Saccharomyces cerevisiae
trifluperidol
-
 Yarrowia lipolytica
U18666A
-
 [Candida] glabrata
U18666A
-
 Homo sapiens
U18666A
-
 Saccharomyces cerevisiae
U18666A
-
 Yarrowia lipolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
zymostenol Homo sapiens
-
 lathosterol
-
 ?
zymostenol Saccharomyces cerevisiae
-
 lathosterol
-
 ?
zymostenol Yarrowia lipolytica
-
 lathosterol
-
 ?
zymostenol [Candida] glabrata
-
 lathosterol
-
 ?
zymosterol Homo sapiens primary substrate cholesta-7,24-dienol
-
 ?
zymosterol Saccharomyces cerevisiae primary substrate cholesta-7,24-dienol
-
 ?
zymosterol Yarrowia lipolytica primary substrate cholesta-7,24-dienol
-
 ?
zymosterol [Candida] glabrata primary substrate cholesta-7,24-dienol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-
Yarrowia lipolytica
-
-
-
[Candida] glabrata
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
zymostenol
-
 Homo sapiens lathosterol
-
 ?
zymostenol
-
 Saccharomyces cerevisiae lathosterol
-
 ?
zymostenol
-
 Yarrowia lipolytica lathosterol
-
 ?
zymostenol
-
 [Candida] glabrata lathosterol
-
 ?
zymosterol primary substrate Homo sapiens cholesta-7,24-dienol
-
 ?
zymosterol primary substrate Saccharomyces cerevisiae cholesta-7,24-dienol
-
 ?
zymosterol primary substrate Yarrowia lipolytica cholesta-7,24-dienol
-
 ?
zymosterol primary substrate [Candida] glabrata cholesta-7,24-dienol
-
 ?

Synonyms

Synonyms Comment Organism
DELTA8,7-sterol isomerase
-
 Homo sapiens
DELTA8,7-sterol isomerase
-
 Saccharomyces cerevisiae
DELTA8,7-sterol isomerase
-
 Yarrowia lipolytica
DELTA8,7-sterol isomerase
-
 [Candida] glabrata
EBP
-
 Homo sapiens
EBP
-
 Saccharomyces cerevisiae
EBP
-
 Yarrowia lipolytica
EBP
-
 [Candida] glabrata
emopamil-binding protein
-
 Homo sapiens
emopamil-binding protein
-
 Saccharomyces cerevisiae
emopamil-binding protein
-
 Yarrowia lipolytica
emopamil-binding protein
-
 [Candida] glabrata