Literature summary for 5.3.3.5 extracted from

Cho, S.Y.; Kim, J.H.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: differential inhibition of sterol DELTA8-isomerase and other lanosterol-converting enzymes by tamoxifen (1998), Mol. Cells, 8, 233-239.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy]-N,N-dimethylethanamine	noncompetitive, IC50: 0.00025 mM	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
DELTA8-SI	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00021	-	tamoxifen	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00025	-	noncompetitive, IC50: 0.00025 mM	Rattus norvegicus	2-[4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy]-N,N-dimethylethanamine

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Release 2023.1 (January 2023)