Literature summary for 5.3.3.12 extracted from

Jiao, Z.; Zhang, Z.G.; Hornyak, T.J.; Hozeska, A.; Zhang, R.L.; Wang, Y.; Wang, L.; Roberts, C.; Strickland, F.M.; Chopp, M.
Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation (2006), Dev. Biol., 296, 396-408.

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	recombinant enzyme Dct-lacZ fusion protein	-

Source Tissue	Comment	Organism	Textmining
brain	measuring of the spatial and temporal pattern of enzyme expression in vivo during neocortical neurogenesis. Enzyme is expressed in all layers of the dorsal telencephalon in E10.5. At E15.5 and E17.5, expression is primarily localized to the ventricular zone. Blocking endogenous enzyme by RNAi decreases proliferation of embryoic cortical neural progenitor cells. In adult brain, strong expression is observed in rostral migratory stream and septum. Overexpression of enzyme in subventricular zone cells of adult mice significantly increases the number of cells, whereas silencing Dct enzyme by RNAi decreases the cell number	Mus musculus	-
neural progenitor cell	blocking endogenous enzyme by RNAi decreases proliferation of embryoic cortical neural progenitor cells	Mus musculus	-
rostral migratory stream	strong expression in adult	Mus musculus	-
septum pellucidum	strong expression in adult	Mus musculus	-
subventricular zone	overexpression of enzyme in subventricular zone cells of adult mice significantly increases the number of cells, whereas silencing Dct enzyme by RNAi decreases the cell number	Mus musculus	-
telencephalon	enzyme is expressed in all layers of the dorsal telencephalon in E10.5	Mus musculus	-
ventricular zone	at E15.5 and E17.5, enzyme expression is primarily localized to the ventricular zone	Mus musculus	-