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Literature summary for 5.3.3.1 extracted from
- Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones (1999), J. Steroid Biochem. Mol. Biol., 71, 191-202.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 17beta-estradiol | IC50: 0.0003 mM | Bos taurus |  |
| Biochanin A | IC50: 0.0004 mM | Bos taurus | |
| daidzein | IC50: 0.0038 mM | Bos taurus | |
| formononetin | IC50: 0.004 mM | Bos taurus | |
| genistein | IC50: 0.0023 mM | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
DELTA5-pregnen-3,20-dione | 25°C, pH 7.5 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
3beta-hydroxy-5-ene-steroid dehydrogenase/steroid DELTA5-DELTA4-ene isomerase enzyme complex | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 3beta-hydroxy-5-ene-steroid dehydrogenase/steroid DELTA5-DELTA4-ene isomerase enzyme complex | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DELTA5-pregnen-3,20-dione | - |
Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-HSD/isomerase | - |
Bos taurus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.303 | - |
DELTA5-pregnen-3,20-dione | 25°C, pH 7.5 | Bos taurus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
IC50: 0.0003 mM | Bos taurus | 17beta-estradiol | |
| 0.0004 | - |
IC50: 0.0004 mM | Bos taurus | Biochanin A | |
| 0.0023 | - |
IC50: 0.0023 mM | Bos taurus | genistein | |
| 0.0038 | - |
IC50: 0.0038 mM | Bos taurus | daidzein | |
| 0.004 | - |
IC50: 0.004 mM | Bos taurus | formononetin | |
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Release 2023.1 (January 2023)
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