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Literature summary for 5.3.1.9 extracted from
- Cryptococcal phosphoglucose isomerase is required for virulence factor production, cell wall integrity and stress resistance (2015), FEMS Yeast Res., 15, fov072 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cryptococcus neoformans | - |
- |
- |
| Cryptococcus neoformans 4500FOA | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pgi1 | - |
Cryptococcus neoformans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a leaky mutant expressing PGI1 at a level of 1.9% of the wild type, is able to synthesize the pigment melanin in the presence of 2% glucose. Capsule biosynthesis is remarkably reduced in the mutant, integrity of the cell wall and plasma membrane are impaired. The mutant exhibits hypersensitivity to osmotic stress generated by 2 M NaCl or 1 M KCl and fails to utilize mannose and fructose | Cryptococcus neoformans |
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Release 2023.1 (January 2023)
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